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Novartis Commits $12 Billion Cash to Acquire U.S. Biotech Avidity Biosciences

Swaraj Swaraj
|
Published on November 4, 2025
Novartis is acquiring Avidity Biosciences for 12 billion dollar

Swiss pharmaceutical company Novartis AG announced on Sunday that it will acquire U.S.-based biotech firm Avidity Biosciences for approximately US $12 billion, in a move to expand its footprint in rare ­disease and neuromuscular therapies. 

Under the terms of the all-cash deal, Avidity shareholders will receive $72 per share, representing a premium of about 46 % over the company’s closing price on Friday. Avidity, based in San Diego, specialises in RNA-based therapeutics targeting muscle disorders, a field in which Novartis has sought stronger positioning amid looming patent expirations of key drugs.  As part of the transaction, Avidity will spin off its early-stage precision cardiology programmes into a newly created public entity, to be called “SpinCo”. 

That unit will remain independent while the core deal moves forward. Novartis expects the acquisition to further its strategy of deepening engagement in highly specialised treatment areas, particularly for conditions with few existing options. The deal builds on Novartis’s recent run of strategic transactions. Earlier this year, it acquired or entered into tie-ups with several companies in genetics and rare-disease spaces to bolster its pipeline and offset risk from blockbuster blocks facing generic competition. 

ALSO READ: Trump Threatens 250% Tariffs on Drug Imports in Push for Domestic Manufacturing

Avidity Biosciences

For Novartis, gaining access to Avidity’s platform for delivering RNA directly to muscle tissue represents a key stepping stone into next-generation therapies. The companies expect the deal to close in the first half of 2026, subject to customary approvals, including shareholder consent and regulatory clearance, as well as completion of the SpinCo separation. The immediate infusion of assets strengthens Novartis’s U.S. presence and rare-disease portfolio. 

Analysts note that the success of the venture will depend heavily on the execution of Avidity’s clinical programmes and the integration of its technology platform. In sum, the transaction marks a sizable bet by Novartis on the future of RNA therapeutics within neuromuscular disease, and signals its intent to pivot into higher-growth, science-driven areas.

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